HISTORY OF IMMUNOMETABOLIC REMEDIES
introduction of the new Syntrion remedies into the American market, there are
now 3 lines of immunometabolic remedies available, each from a different
manufacturer in Germany, and each having distinctly different qualities and
Although referred to as isopathics and not immunometabolics, the initial
remedies in this class introduced to the US were those manufactured by the
Sanum-Kehlbeck company. These remedies most closely conform to the traditional
production methods developed by Gunther Enderlein and his compatriots in the
1920s. Indeed, the company still adheres to some of the terminology and
espouses a clinical model largely unchanged from the time of Enderlein. Remedies
in this product line are manufactured using cultures of various fungi and
bacteria. The exact manufacturing process is a proprietary secret, but the
remedies are prepared using a method that carefully rinses away the interior of
the cell and any metabolic products found in the culture medium, essentially
harvesting the cell wall. This preparation is then put into various homeopathic
dilutions and sold as tablets, capsules, suppositories, drops, and drops in
The Sanum remedies can be used to induce biological effects in clinical
practice, and are often favored by those practitioners who wish to induce an
exuberant cytokine response to strongly modulate the immune response. It
is easy to see how they can do so, in that immunology textbooks abound with
information about cytokine responses that can be induced by bacterial
lipopolysaccharide, found in the cell wall. We used these remedies with
success in clinical practice for years, but found that, with certain remedies,
care is needed so as not to overly upregulate a systemic inflammatory response
while trying to clean up various latent infections and toxic foci from the
A second manufacturer is SanPharma, a family-owned company. For one year,
Syntrion founder Ronald Ullmann served as president of SanPharma, during which
time he introduced several changes that represented major modernization steps in
the production of these microbial remedies. Ullmanns research led him to
believe that the beneficial biological effects of the remedies come from
metabolites produced by the organisms, but that the pro-inflammatory side
effects come from the cell wall fragments present in the remedies. He then
changed production methods to exclude cell wall fragments and include only
metabolic products from the microbes. The result was the new generation of
SanPharma remedies, which enabled us to get the desirable effects in our
clinical practice with far fewer adverse reactions. Eventually, we discontinued
using the Sanum-Kehlbeck remedies, and switched to using the SanPharma line, and
in doing so our clinical successes improved. Specifically, we found that we
could now safely induce a downregulation of systemic inflammation while at the
same time reducing immune hyper-reactivity and also taking the immune system out
A recent article written by Gitte Jensen, Ph.D. and published in the
peer-reviewed Journal of Alternative and Complementary Medicine supports our
clinical findings. In the article, Dr. Jensen presents her research on the
SanPharma fungal remedies and points out that the SanPharma remedy Notatum
which we considered anti-inflammatory reduced the baseline of COX-2 enzymes in
Finally, after making key improvements to the SanPharma line, Ronald Ullmann
left the SanPharma company to continue his research into the possibilities of
microbial-based remedies. His research involved studying the effects of specific
microbial metabolites on various human cell lines including immune system cells.
He developed a way of harvesting specific microbial metabolites, and preparing
specific homeopathic preparations of these materials. In other words, rather
than making a remedy that contains all of the metabolic products from s
particular organism, he learned to tune the effect of the remedies by
harvesting only specific metabolites that were shown to be beneficial. The
result is the new Syntrion line of microbial remedies.
SYNTRION IMMUNOMETABOLIC REMEDIES
Syntrion remedies are derived from specific metabolites of various fungal
organisms, which are harvested and prepared in a D4 homeopathic preparation.
They are available in the form of tablets and lotions.
The products that will be introduced to the US market in summer 2006 are
SyAllgen, SyCircue, SyImmune and SyRegule tablets, and SyAllgen, SyCircue,
SyImmune, and SyFungin and SyDerm lotions.
DOSAGE AND FREQUENCY
Most patient protocols will involve the use of both the tablets and the
lotion. The tablet is taken by dissolving in the mouth, at least a few
minutes away from food, 3 times per day, or more often for very acute
situations. This gives a systemic effect. It also gives information
to the immune system as can only be accomplished by passing through the
mucosa. The mucosal administration seems to modulate immune system effects
in the gut and upper respiratory system.
The lotion is applied to the appropriate body area twice per day.
Unless otherwise determined by the specific application, use about 1/8 teaspoon
per dose. The lotion focuses the effect of the remedy in the region of the
body that you desire to target. It also has a systemic effect associated
with its transdermal application. Different information is given to the
immune system with a transdermal lotion versus a tablet dissolved in the
mouth. Transdermal application seems to have a systemic effect that favors
the lungs and nervous system.
In our initial trials with these remedies, both the tablet and the lotion are
used. In fact, we often find that neither the tablets or the lotion test
as effective by electrodermal screening, while the combination of both tests
extremely effective. Other times, just one form or the other will be used
successfully. This probably pertains to which type of information the
immune system needs to have the needed response. The use of the tablets
and lotion combined gives the most complete effect.
While we have not given these remedies to enough children to know for sure
whether the dosage recommendations should be altered for them, it appears so far
that the response is more related to frequency of administration than dosage of
administration. Therefore, for now, we are recommending that children be
dosed the same as adults.
SyAllgen is one of the two remedies that will be used at the onset of a case
management. It is used first because it tends to be non-provoking, and
sets the scene for major beneficial changes in the biological terrain.
SyAllgen is made from metabolites harvested from Penicillium
frequentans. Unlike the remedy Quentans from SanPharma, this remedy is
used to downregulate allergic tendencies as well as other types of immunological
Most of the pilot studies done on SyAllgen have been with allergies such as
food sensitivities and hay fever. In our own practice, we have been
encouraged and excited about the degree to which SyAllgen seems to stabilize the
allergic patient. Some symptomatic relief is seen within a few hours to a
few days of starting SyAllgen. But what is more exciting is that the
overall reactivity tends to decrease significantly within about 3 weeks,
resulting in lowered systemic inflammation, better musculoskeletal stability,
and a lowering of the systemic toxic load in patients taking this remedy.
Pilot studies done in Germany with SyAllgen lotion showed a very good and
immediate response in shavers itch, insect bites and atopic dermatitis.
We have used it for sunburn, and find that it reduces the uncomfortable itching,
but not the redness.
We have also used it in bee stings. It doesnt do much for the acute
initial sting. A drop of peppermint oil on the sting will take care of the
acute pain immediately. (Do not place peppermint oil near eyes or other
sensitive orifices.) The SyAllgen will then take care of the delayed
histamine reaction that occurs in the hours to days following the sting.
We do not yet know if prolonged treatment with SyAllgen will reduce the severity
of the reaction to bee stings in highly allergic people who are required to
carry an epi-pen to treat anaphylaxis. However, it does a good job of
reducing the severity of other types of allergic reactions, so this application
would be a worthwhile one to try.
In vitro studies on immune system cell lines done in Germany showed that
SyAllgen prevents the over-induction of immune system activity that occurs when
immune system cells are exposed to various toxins. This implies that
SyAllgen may be the remedy of choice for reducing the TH1 overstimulation in
autoimmune conditions. We have not had enough time with this remedy to
determine to what extent this is true, but have found it to be very good for
reducing systemic inflammatory upregulation.
The reduction in systemic inflammation is partially, but not completely,
related to its ability to downregulate COX-2. All of the Syntrion are
COX-2 downregulators, but their effects are not just related to COX-2.
Regarding the mechanism of reducing allergic sensitivity, SyAllgen was found
to reduce mast cell motility and histamine release.
Thus, think of SyAllgen for immune system hyper-reactivity, whether it be TH1
or TH2 fixation. This makes SyAllgen a major first remedy to use in the
beginning of a case management. When applicable, SyAllgen will be used as
the initial remedy in the majority of cases, for a duration of 6 weeks to 3
SyAllgen combines well with SyRegule/SyFungin or SyImmune, but initial
treatment with SyAllgen alone is usually necessary. We have not yet seen
cases where SyAllgen and SyCircue are used systemically at the same time, unless
the SyCircue is being used topically for a local condition.
SyAllgen combines well with any of the PEKANA remedies. If being used for
basic anti-inflammatory and terrain regulation purposes, the Basic Detox Kit
would commonly be chosen to use with SyAllgen. If hay fever is being treated,
ProAller and Ricura may be the PEKANA remedies of choice. To target the
effects of SyAllgen to the gut, combining with Apo-Stom works quite nicely. In
later stages of treatment, where key toxins are being liberated from deep tissue
foci, the addition of SyAllgen prevents many of the reactions that are
attributed to the movement of the toxins inducing a cytokine response.
To summarize, SyAllgen will be used for 3 purposes:
- Reduction of systemic inflammation and immune system hyper-reactivity at
the onset of a case management.
- Any time allergic symptoms are present.
- Later in case management when key toxins are being liberated while toxic
foci are being cleansed, to prevent adverse reactions.
Nutritional products that should be used with SyAllgen include the usual
anti-inflammatory products, such as omega 3 fatty acids, B vitamins such as B12
and folate to support homocysteine transmethylation, and anti-oxidants,
especially flavenoids like quercitin.
SyCircue is prepared from metabolites harvested from Mucor racemosis.
Research done at Syntrion using umbilical cells determined that certain
metabolites of Mucor have an effect on endothelial cell differentiation. In the
presence of inflammation and of certain toxins, the endothelial cells will
partially de-differentiate, and new cells will be prevented from fully
differentiating. This partial de-differentiation causes all kinds of mischief in
the circulatory beds. Communication between the bloodstream and the matrix is
compromised. The result is that toxins do not drain well from the matrix, and
nutrients and regulating molecules do not reach the tissues properly. The use of
SyCircue provides the signals that force a full endothelial differentiation,
thus clearing up all sorts of circulatory problems.
In clinical practice, we constantly see cases where a toxic load or an
upregulation of systemic inflammation will create a regulatory blockade. Our
experience with SyCircue suggest that this blockade may be due in large part to
this pro-inflammatory endothelial partial de-differentiation. Use of SyCircue
resolves this issue in a manner which does not tend to be provoking. In fact, it
appears that the addition of SyCircue to a program of PEKANA remedies that has
created some symptomatic aggravation is much more likely to quell the adverse
symptoms of toxin download than it is to cause further aggravation.
Having just said that, our opinion may be colored by the fact that we always
add adequate drainage medicines to a protocol that uses immunometabolic
remedies. It is possible that the outpouring of toxic waste that has been
trapped in the matrix, as occurs when SyCircue is used, would cause adverse
symptoms if not properly buffered with Pekana remedies. The fact that we
have not seen any adverse responses with SyCircue could be either that the
SyCircue has enough anti-inflammatory effects in its own right, or that we have
so far been fortunate enough to always have chosen the appropriate Pekana
medicines with the SyCircue.
This means that SyCircue is often the first remedy used in a case
management, or the second remedy after treatment with SyAllgen.
Any time that the correct PEKANA remedies have been chosen, but are not creating
as much clinical change as you would expect, consider adding SyCircue. The
resolution of the circulatory regulatory blockade just might put the progression
of the case right on track. Similarly, if the first Syntrion remedy given
was SyAllgen, but not much clinical improvement occurred, This means that the
actual correct first remedy was either SyCircue or SyRegule.
Some interesting pilot studies have been done in Germany on SyCircue. One
involved a number of glaucoma patients. They were given 1 tablet of SyCircue
orally 3 times per day and instructed to rub the SyCircue lotion into the
periorbital tissue 2 times per day. Follow-up in 4 weeks showed normal
intra-ocular pressure in all test subjects.
Studies on bruising showed improved healing time with use of the lotion.
Another study on decubitus ulcers showed good improvement, which was further
improved when SyCircue and SyImmune were used together.
We find the SyCircue effective for simple muscular soreness. Muscular pain
from over-exertion seems to respond very quickly to SyCircue. In this
application, SyCircue and Inflamyar seem to enhance each other's effects.
An effective use of the two remedies is to massage Inflamyar into sore muscles,
then choose a few spots where the tissue stays indurated and painful despite the
Inflamyar application, and massage a dollop of SyCircue into these spots.
In my practice, I do lots of Chinese cupping therapy. Regions on the back
corresponding to visceral blood stasis that do not resolve with cupping tend to
respond to a combination of cupping and bleeding. When SyCircue is used as the
lubricant for cupping therapy, the bleeding is usually not needed.
Another anecdote from our practice is the use of SyCircue in 2 patients
experiencing unresolved extreme ankle soreness for 2 or more weeks following a
deep vein thrombosis episode. Application of the SyCircue resolved much of
that pain within 2 days.
Some interesting patterns have been seen in combining SyCircue with Pekana
and SanPharma remedies. Sometimes a fairly large dose of Pekana drainage
medicine is needed in the first 2-4 weeks of using SyCircue. An example
might be Itires taken ¾ teaspoon per dose, or Opsonat taken 25 or 30 drops per
dose, or Toxex taken 25 drops per dose. Use extreme caution and monitor
closely if larger than average doses of potentially provoking remedies are being
given. But, we have given these larger doses with SyCircue in a few dozen
cases now without incident.
One explanation for this might be that the larger doses of drainage are
needed to download the regulatory blockade that has been preventing the matrix
from discharging its load of toxins into the bloodstream for elimination, and
this blockade was caused by circulatory problems at the level of the
vascular-matrix interface. SyCircue resolves the vascular problem and
restores the ability of the matrix to detoxify properly.
Another interesting pattern is the combining of a SyCircue program with
frequent doses of Cereus or Firmus. Some patients have required as much as
5 doses per week of one of these bacterial remedies, which would normally
be too provoking for most patients.
So, now we have 2 remedies that can be used as the first remedy in a new
case. Choose SyAllgen if there are symptoms of allergy or autoimmune
inflammation. Choose SyCircue if there are signs of circulatory blockade. Signs
of circulatory blockade would be soreness and induration in tissues, darkened
coloration, presence of spider veins, etc. It does not seem appropriate to
use both of these medicines simultaneously.
Once the patient has used one of these 2 remedies for long enough to give
significant improvement, they can move on to either SyImmune or
SyRegule/SyFungin if indicated.
SyImmune is prepared from metabolites harvested from Penicillium
notatum. Metabolites were chosen that enhance the immune system's response
to all kinds of microbial infections. The majority of the research has been done
with viral infections, but the remedy is not limited in application to
In an acute infection, non-specific immune responses that involve
inflammatory upregulation do their best to contain the infection until an
antibody response can be generated. In the lag time between the onset of
the infection and development of the full adaptive immune response, the patient
can feel very sick due to cytokine upregulation, which produces fever, aches,
malaise, etc. Use of SyImmune collapses the time needed for the
development of the adaptive immune response. The result is that the
patient develops immunity to the pathogen in less time, and the infection
resolves more quickly.
In cell line experiments, communication between CD4 cells and macrophages was
seen to improve. Antigen recognition of Candida was increased. Modulation of
various interleukins was studied, with strong effects on IL-1 found.
Some of the most dramatic pilot studies were with herpes lesions. Application
of SyImmune directly to the skin lesions gave a favorable response even in
herpes sores that were unresponsive to Valtrex.
Similarly, the SyImmune lotion has been used with plantar warts. We do
not yet have experience regarding venereal warts.
In early sore throat, we have seen good response to applying the lotion to
the cervical lymph nodes. In fact, we have seen several cases where an
early sore throat of mild to moderate severity, complete with low-grade fever,
was cleared up in about 20 minutes after one application of the SyImmune
lotion. This represents a better-than-average response to this remedy.
Another German pilot study showed more rapid recovery from influenza in a
protocol where 1 tablet was given per hour up to 6/day until improvement noted,
then dosage was reduced to 1 tablet every 2 hours, then to 3/day. Another study
was done on ear infections using the same oral dosing as for flu, but adding the
topical lotion applied 2 times per day to cervical lymph nodes and behind the
It would seem that SyImmune is for upregulating the immune response against
microbial infection, and for taking the immune system out of an anergic
state. However, this is accomplished without upregulating the inflammatory
Complementary to this is SyAllgen, which downregulates an over-stimulated
immune system. In combination, these two medicines can be used together to
restore dynamic immune system regulation. We have seen several cases
respond well to a combination of SyAllgen and SyImmune, using one tablet of each
3 times per day and a dab of each lotion on the cervical lymphatics twice per
day, in patients with chronic infections and chronic inflammation. Some of these
patients seem to be able to start both medicines right away, and another subset
of patients seem to need to start with the SyAllgen alone for 2 weeks before
adding the SyImmune.
Detailed Syntrion Product Discussion - Continued