VPS®
Coriolus Versicolor
Fruit Body Cell Wall Extract
Min. 35% 1-4, 1-3 Protein-Bound Polysaccharide
150 Caps: $84.95
60 Caps: $39.95
 Coriolus Versicolor - VPS
Over 300 published studies have been conducted on the
immuno-modulating* properties of the 1-4,1-3 proteoglycans
extracted from the cell walls of Coriolus Versicolor - VPS,
including 24 human studies (14 controlled, randomized, human
clinical trials). With over $350 million in annual sales in
Japan, this cell-wall extract has become one of the most widely
used supplements in the world for supporting immune health.*
Decoctions of Coriolus Versicolor - VPS have been used for
centuries in Traditional Chinese Medicine, with references in the
Chinese Compendium of Materia Medica dating as far back as the
15th century. The Ming dynasty edition states that "The
black and green Yun zhi are beneficial to one's spirit and
vital energy, and strengthen one's tendon and bone. If Yun
zhi is taken for a long time, it will make one vigorous and live
long."
How Supplied
60 Vcaps, 150 Vcaps
625 mg per Vcap
Indications
Immune modulation,* hepatic support.* Used for serious immune
support,* especially indicated in those situations where the
white blood count is suppressed.
Instructions For Use
Two to three capsules two times daily. For maximum dose, use no
less than 3000 mg of extract per day with a minimum of 34-40%
polysaccharide content.
Toxicity, Cautions,
Contraindications
Coriolus polysaccharides are safe and nontoxic, having been used
daily in clinical studies lasting five to ten years. However,
immuno-modulating substances should be used with extreme care or
avoided completely in organ-transplant patients utilizing
immuno-suppressive agents.
Clinical Research
The research suggests that the polysaccharide portion of the
extract may enhance the cell-mediated immune response.* Although
the mechanism of action is not clearly understood, the 1-4,1-3
proteoglycans act as a biological response modifier and have been
found to support and enhance Natural Killer cell function, to
stimulate depressed lymphocyte proliferation, and to support the
healthy growth of white blood cells.*1,2,3 Also, the research shows these constituents to
be effective in supporting normal cell growth, improving
cell-mediated cytotoxicity, and increasing interleukin-2
production and T-cell proliferation.*4,5,6
Selected Clinical
Studies
The results of an eight-year clinical trial, published in 1990,
recorded substantial benefit from daily use of the Coriolus
1-4,1-3 extract. The group receiving the Coriolus extract
experienced a significant improvement in immune health* over the
group receiving the placebo, with the leukocyte activity of the
Coriolus group showing "remarkable enhancement." It was
concluded that "the beneficial effects were probably due to
the activation of leukocyte function* as one of the many
biological-response-modifying activities induced by
(Coriolus)."7 In a study published in Lancet, Coriolus was
found to have a "restorative effect in patients who have
been immuno-suppressed" and were experiencing depressed
white blood counts.*8
Traditional Use And
Preparation
Coriolus is sweet in taste and slightly warm in nature, acting
through the spleen and heart meridians. It dispels damp and
reduces phlegm.9
In Traditional Chinese Medicine Coriolus is prepared as a
hot-water extraction/decoction.10 Coriolus is never used in the un-extracted
form or prepared as a cold-process tincture.
Active Constituents
Heavy Molecular Weight Polysaccharides ( 1-4,1-3
proteoglycans)
Extraction Information
Hot-water extracts from both the fruit body and the mycelium are
used in current clinical practice and research. The active
constituents, the polysaccharides, are found in the cell walls of
both, although extracts from the fruit body have shown higher
levels of immune activity* with oral use.11 VPS® is isolated
through a multi-step hot-water extraction process, creating a
high concentration of the 1-4,1-3 cell-wall constituents used in
the Japanese research. As these compounds are difficult to
extract and easily degraded with excessive heat NMR and linkage
analysis are used to ensure product quality.
Description
Latin ... Coriolus versicolor, Trametes
versicolor
Chinese ... Yun zhi (Cloud Mushroom)
Japanese ... Kawaratake
Common Name ... Turkey Tail
Coriolus versicolor belongs to the family Polyporaceae
and is found throughout the wooded temperate zones of North
America, Asia, and Europe. Found predominantly on hardwoods, the
thin, woody, shelf-like fruit bodies form dense overlapping
clusters on the sides of stumps and fallen trees. The fruit
bodies (mushrooms) have a plush, velvety surface, are colored in
varying shades of gray or brown, and have a distinctive pattern
of alternating bands of dark and light color. The bottom is cream
colored and porous.
References
- Ooi, V.E., Liu, F., Immuno-modulation and
anti-cancer activity of polysaccharide-protein complexes. Curr
Med Chem 2000 Jul;7(7):715-29.
- Fujui, T.et al. Effect of PSK on prohibited
immunity of splenectomized mice. Anticancer Res 1987 Jul-Aug;
7(48):845-8.
- Kobayashi, H., et al., PSK as a
chemopreventative agent. Cancer Epidemiol Biomarkers Prev 1993
May-Jun; 2(3):271-6.
- Tsukagoshi, S., et al., Krestin (PSK) Cancer
Treat Rev 1984 Jun; 11(2):131-55.
- Kobayashi, H., et al., Antimetastatic effects
of PSK (Krestin), a protein-bound polysaccharide obtained from
basidiomycetes: an overview. Cancer Epidemiol Biomarkers Prev
1995 Apr-May; 4(3):275-81.
- Kanoh, T., et al., Enhancement of the
antitumor effect by the concurrent use of a monoclonal antibody
and the protein-bound polysaccharide PSK in mice bearing a human
cancer cell line. In Vivo 1994 Mar-Apr; 8(2): 241-5.
- Torisu, M., et al., Significant prolongation
of disease-free period gained by oral polysaccharide K (PSK)
administration after curative surgical operation of colon cancer.
Cancer Immunology Immunotherapy. 1990; 31:261-268.
- Nakazato, H., et al., Efficacy of
immunochemo-therapy as adjuvant treatment after curative
resection of gastric cancer. Lancet, 343-1122-1126. 1994;
- Hobbs, C., Medicinal Mushrooms, Botanica
Press,1995.
- Liu, B., Bau, Y., Fungi Pharmacopoeia.
Kiniko Press, 1980.
- Hotta, et al.,U.S. Patent
#4,271,151.1981.
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